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Also, the women with physically demanding jobs going through IVF had a lower total reserve of eggs and fewer mature eggs than those whose jobs did not entail heavy lifting. Furthermore, these differences were even more marked among women working shifts, particularly those rostered on during evenings and nights or where shift patterns fluctuated. The researchers say this probably reflects disruption to the body's internal clock. Age and weight also played a part. Women who were overweight, with a body mass index (BMI) of 25 or more, and who had physically demanding jobs, also had fewer mature eggs than those of the same weight who didn't have to do any heavy lifting. The researchers caution that they can't prove cause and effect because they carried out an observational study using third party data. Commenting on the findings in a statement, Dr Channa Jayasena, clinical senior lecturer in endocrinology at Imperial College London, says: "We already know that physical exertion and stress can inhibit the female reproductive system and make periods less regular or even absent. Workers are increasingly moving away from a traditional 9 to 5 model, and we still know very little about how this could affect our health. "This study is too small to rule out that the shift and manual labour workers were exposed to something else that made them less fertile. For example, it is possible that they were poorer and therefore had different social conditions or diet, compared with the 9 to 5 workers. In any case, the results help us understand how our work life can impact on our reproductive health." Alastair Sutcliffe, professor of paediatrics at University College London, comments in a statement: "Human beings like light.
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